Open AccessFrom gene regulation to gene function: regulatory networks in Bacillus subtilis
Author(s) -
Harwood Colin R,
Moszer Ivan
Publication year - 2002
Publication title -
comparative and functional genomics
Language(s) - English
Resource type - Journals
eISSN - 1532-6268
pISSN - 1531-6912
DOI - 10.1002/cfg.138
Subject(s) - bacillus subtilis , in silico , computational biology , organism , gene , biology , model organism , function (biology) , genome , genetics , bioinformatics , bacteria
Bacillus subtilis is a sporulating Gram‐positive bacterium thatlives primarily in the soil and associated water sources. The publicationof the B. subtilis genome sequence and subsequent systematic functionalanalysis and gene regulation programmes, together with an extensive understandingof its biochemistry and physiology, makes this micro‐organism a prime candidatein which to model regulatory networks in silico . In this paper we discusscombined molecular biological and bioinformatical approaches that are beingdeveloped to model this organism's responses to changes in its environment. Copyright © 2001 John Wiley & Sons, Ltd.