Open AccessClinical trial of combined radio‐ and fluorescence‐guided sentinel lymph node biopsy in breast cancer
Author(s) -
Schaafsma B. E.,
Verbeek F. P. R.,
Rietbergen D. D. D.,
Hiel B.,
Vorst J. R.,
Liefers G. J.,
Frangioni J. V.,
Velde C. J. H.,
Leeuwen F. W. B.,
Vahrmeijer A. L.
Publication year - 2013
Publication title -
british journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.202
H-Index - 201
eISSN - 1365-2168
pISSN - 0007-1323
DOI - 10.1002/bjs.9159
Subject(s) - medicine , sentinel lymph node , indocyanine green , breast cancer , biopsy , nuclear medicine , lymphatic system , lymph , gamma probe , radioactive tracer , radiology , cancer , surgery , pathology
Combining radioactive colloids and a near-infrared (NIR) fluorophore permits preoperative planning and intraoperative localization of deeply located sentinel lymph nodes (SLNs) with direct optical guidance by a single lymphatic tracer. The aim of this clinical trial was to evaluate and optimize a hybrid NIR fluorescence and radioactive tracer for SLN detection in patients with breast cancer.