Open AccessPossible association between genetic polymorphisms in transforming growth factor β receptors, serum transforming growth factor β1 concentration and abdominal aortic aneurysm
Author(s) -
Golledge J.,
Clancy P.,
Jones G. T.,
Cooper M.,
Palmer L. J.,
van Rij A. M.,
Norman P. E.
Publication year - 2009
Publication title -
british journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.202
H-Index - 201
eISSN - 1365-2168
pISSN - 0007-1323
DOI - 10.1002/bjs.6633
Subject(s) - medicine , odds ratio , single nucleotide polymorphism , abdominal aortic aneurysm , snp , cohort , confidence interval , transforming growth factor , gastroenterology , aortic aneurysm , thoracic aortic aneurysm , aneurysm , endocrinology , oncology , genotype , surgery , genetics , gene , biology , aorta
Background: Previous studies have suggested a role for transforming growth factor (TGF) β and its receptor in thoracic aortic aneurysm, but their role in abdominal aortic aneurysm (AAA) is unknown. This study examined the possible association between TGF‐β receptor 1 and 2 ( TGFBR‐1 and ‐ 2 ) single nucleotide polymorphisms (SNPs) and serum TGF‐β1 with AAA. Methods: Serum concentrations of TGF‐β1 and 58 SNPs for TGFBR‐1 and ‐ 2 were examined in 1003 and 1711 men respectively from the Health In Men Study. Validation of SNPs was examined in a second referral cohort of 1043 subjects from New Zealand, of whom 654 had an AAA. Results: Serum TGF‐β1 was not associated with AAA. Only one SNP in TGFBR‐2 was weakly associated with AAA; TGFBR2 g.42917C > T, SNP ID rs1078985CC; odds ratio 0·64 (95 per cent confidence interval (c.i.) 0·45 to 0·93); P = 0·020 uncorrected; but this association did not hold after adjusting for multiple testing and was not validated in the New Zealand cohort: odds ratio 0·98 (95 per cent c.i. 0·50 to 1·94); P = 0·960. Conclusion: These findings suggest there is no important role of genetic polymorphisms in the main receptors for TGF‐β and circulating TGF‐β1 in AAA in older individuals. Copyright © 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.