Open AccessThe effects of N‐acetylcysteine on host inflammatory response and renal function in patients undergoing infra‐inguinal bypass surgery
Author(s) -
Sharif M. A.,
Badger S. A.,
O'Donnell M. E.,
Lee B.,
Han R. J.,
Lau L. L.,
Young I. S.,
Soong C. V.
Publication year - 2009
Publication title -
british journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.202
H-Index - 201
eISSN - 1365-2168
pISSN - 0007-1323
DOI - 10.1002/bjs.6497
Subject(s) - medicine , acetylcysteine , surgery , renal function , inflammatory response , inflammation , biochemistry , chemistry , antioxidant
forms at 50kDa. Protein application to human vascular endothelial cells leads to a specific phosphorylation of the Tie2 receptor, maximal at 1 μg/ml for each. Conclusion: Using rational design we have engineered the first small molecular mass ligands for the Tie2 receptor. Two of these ligands have been shown to activate the receptor. Studies are currently underway to test the functional effects of these novel ligands on vascular endothelial apoptosis, leakage and inflammation.