Open AccessHepatic bile acid synthesis and DNA synthetic rate after partial hepatectomy
Author(s) -
Chijiiwa K.,
Kozaki N.,
Naito T.,
Okamoto S.,
Kuroki S.,
Yamashita H.,
Tanaka M.
Publication year - 1996
Publication title -
british journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.202
H-Index - 201
eISSN - 1365-2168
pISSN - 0007-1323
DOI - 10.1002/bjs.1800830414
Subject(s) - hepatectomy , dna synthesis , medicine , bile acid , liver regeneration , enzyme , endocrinology , dna , regeneration (biology) , surgery , biochemistry , biology , resection , microbiology and biotechnology
Abstract The relationship between hepatic DNA synthetic rate and activity of cholesterol 7α‐hydroxylase, the rate limiting enzyme for bile acid synthesis, was examined in regenerating liver after partial hepatectomy or sham operation in rats. Hepatic cholesterol 7α‐hydroxylase activity was significantly (P< 0·001) suppressed on days 1 and 2, returned to the control level on day 3, and was significantly raised on day 7 after hepatectomy. The rate of DNA synthesis was significantly (P< 0·001) activated during the first 3 days after hepatectomy and returned to the control level on day 7. Enzyme activities regulating hepatic bile acid synthesis and DNA synthesis change inversely during liver regeneration after hepatectomy.