Open AccessPoor survival after resection of early gastric cancer: extremes of survivorship analysis reveal distinct genomic profile
Author(s) -
Datta J.,
Da Silva E. M.,
Kandoth C.,
Song T.,
Russo A. E.,
Hernandez J. M.,
Taylor B. S.,
Janjigian Y. Y.,
Tang L. H.,
Solit D. B.,
Strong V. E.
Publication year - 2020
Publication title -
british journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.202
H-Index - 201
eISSN - 1365-2168
pISSN - 0007-1323
DOI - 10.1002/bjs.11443
Subject(s) - medicine , survivorship curve , resection , cancer , survival analysis , surgical resection , oncology , surgery
A subset of patients with early gastric cancer demonstrate early recurrence and poor survival despite margin‐negative resection. This study used an extremes‐of‐survivorship approach to identify an association between TP53 hotspot mutations co‐occurring with loss of heterozygosity and unexpectedly poor survival in early gastric cancer. This distinct genomic profile may be a novel biomarker of poor survival in patients with completely resected early gastric cancer, and warrants large‐scale validation.Promising, validation needed