Open AccessEffect of preoperative injection of superparamagnetic iron oxide particles on rates of sentinel lymph node dissection in women undergoing surgery for ductal carcinoma in situ (SentiNot study)
Author(s) -
Karakatsanis A.,
Hersi A.F.,
Pistiolis L.,
Olofsson Bagge R.,
Lykoudis P. M.,
Eriksson S.,
Wärnberg F.
Publication year - 2019
Publication title -
british journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.202
H-Index - 201
eISSN - 1365-2168
pISSN - 0007-1323
DOI - 10.1002/bjs.11110
Subject(s) - medicine , sentinel lymph node , ductal carcinoma , mastectomy , surgery , breast cancer , dissection (medical) , sentinel node , lymph node , breast surgery , axillary lymph node dissection , breast conserving surgery , radiology , cancer
One-fifth of patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) have invasive breast cancer (IBC) on definitive histology. Sentinel lymph node dissection (SLND) is performed in almost half of women having surgery for DCIS in Sweden. The aim of the present study was to try to minimize unnecessary SLND by injecting superparamagnetic iron oxide (SPIO) nanoparticles at the time of primary breast surgery, enabling SLND to be performed later, if IBC is found in the primary specimen.