Open AccessIndependent association of anti–β 2 ‐glycoprotein I antibodies with macrovascular disease and mortality in scleroderma patients
Author(s) -
Boin Francesco,
Franchini Stefano,
Colantuoni Elizabeth,
Rosen Antony,
Wigley Fredrick M.,
CasciolaRosen Livia
Publication year - 2009
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.24684
Subject(s) - medicine , odds ratio , scleroderma (fungus) , macrovascular disease , disease , cardiology , gastroenterology , pathology , diabetes mellitus , endocrinology , type 2 diabetes , inoculation
Objective Systemic sclerosis (SSc; scleroderma) is characterized by a unique widespread vascular involvement that can lead to severe digital ischemia, pulmonary arterial hypertension (PAH), or other organ dysfunction. Microthrombotic events and procoagulation factors such as anti–β2‐glycoprotein I (anti‐β 2 GPI) or anticardiolipin antibodies (aCL) may be implicated in the development of these manifestations. This study was undertaken to investigate whether anti‐β 2 GPI and aCL are correlated with macrovascular disease, including ischemic digital loss and PAH, in SSc patients. Methods Seventy‐five SSc patients with a history of ischemic digital loss and 75 matched SSc controls were evaluated. Anticentromere antibodies (ACAs), anti‐β 2 GPI, and aCL were measured, and clinical associations were determined using conditional and simple logistic regression models. Results Positivity for anti‐β 2 GPI was significantly more frequent in SSc patients with digital loss than in patients without digital loss ( P = 0.017), with the IgA isotype of anti‐β 2 GPI showing the strongest association (odds ratio [OR] 4.0). There was no significant difference in aCL frequency between patients with digital loss and control patients. After adjustment for demographic characteristics, disease type, smoking, and ACA, anti‐β 2 GPI positivity was significantly associated with active digital ischemia (OR 9.4), echocardiographically evident PAH (OR 4.8), and mortality (OR 2.9). ACA positivity was associated with history of digital loss (OR 3.28), but not with PAH or mortality. History of digital loss was strongly associated with increased mortality (OR 12.5). Conclusion Anti‐β 2 GPI is significantly associated with macrovascular disease in SSc and independently predicts mortality. It is unclear whether it has a pathogenetic role or simply reveals the presence of underlying endothelial injury. The use of anti‐β 2 GPI as a biomarker of vascular disease in SSc should be further explored.