Long term uricosuric therapy in gout

The effectiveness of long term uricosuric therapy was evaluated in sixty‐four patients with primary gout. Serum uric acid was reduced to normal in half the patients; the majority manifested a urate diuresis. In seventeen of fifty patients with tophi, these lesions decreased in size. Acute gouty attacks were reduced to less than one per year in forty‐five, patients; the chronic symptoms present in fifty‐one patients improved in forty., Effectiveness of therapy was categorized as good, moderate, and poor, with examples of illustrative cases.