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The dual therapeutic effect of metformin nuclei‐based drugs modified with one of Tulbaghia violacea extract compounds
Author(s) -
Hassan Safaa S.,
Bedir Elaria A.,
Hamza Abd ElRahman M.,
Ahmed Ahmed M.,
Ibrahim Nouran M.,
Abd ElGhany Mahmoud S.,
Khattab Nada N.,
Emeira Bassant M.,
Salama Mabrook M.,
Mohamed Eman F.,
Fayed Dalia B.
Publication year - 2022
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.6804
Subject(s) - chemistry , schiff base , metal , cytotoxicity , ascorbic acid , stereochemistry , combinatorial chemistry , medicinal chemistry , biochemistry , organic chemistry , food science , in vitro
Novel Schiff base was synthesized from the condensation reaction of metformin with [4‐(Diethylamino) benzaldehyde (NBM). Different metal complexes were prepared using Pd (II), Pt (II), Cu (II), and V (IV) metal ions. All complexes showed the nonelectrolytic behavior. So, the expected molecular formulas for complexes were [Pd (NBM)Cl 2 ], [Pt (NBM)Cl 2 ], [Cu (NBM) 2 Cl 2 ] and [VO (NBM) 2 ]. The cytotoxicity of (NBM) Schiff base and its metal complexes on human cancer cell line, MCF‐7, was investigated. V (IV) and Cu (II) complexes showed potential blood glucose lowering effect higher than the commercial metformin drug. VO (II) complex has superior antioxidant activity more than the other synthesized compounds and the standard ascorbic acid. Molecular docking investigation proved the presence of interesting interactions between all synthesized compounds with the active site amino acids of EGFR tyrosine kinase (anticancer activity). The molecular docking of metal complexes has observed effective inhibition for the specific mTOR protein that is expected to aid the growth of the COVID‐19 virus.