Annals of Neurology: Volume 91, Number 2, February 2022

An illustration of lesion network mapping of blindsight‐negative versus blindsight. This begins with representative lesion locations from a blindsight and blindsight‐negative patient. Lesions were consolidated into a single hemisphere for analysis. Connectivity between each lesion location and the rest of the brain was computed using a normative database of resting state functional connectivity from 1000 healthy subjects. Pictured are the connectivity patterns derived from the two representative lesion locations. Connectivity differences between lesion locations from blindsight‐negative (n=35) versus blindsight patients (n=34) were identified using a two‐sample, voxelwise t‐test within a mask of regions previously implicated in blindsight (dark grey). Lesions in blindsight‐negative patients showed greater functional connectivity to the medial pulvinar (pulvinar in blue outline) compared to lesions in blindsight patients. See paper in this issue by Kletenik et al. (pp. 217–224).