Premium
Biomarkers for dementia in Latin American countries: Gaps and opportunities
Author(s) -
Parra Mario A.,
Orellana Paulina,
Leon Tomas,
Victoria Cabello G.,
Henriquez Fernando,
Gomez Rodrigo,
Avalos Constanza,
Damian Andres,
Slachevsky Andrea,
Ibañez Agustin,
Zetterberg Henrik,
Tijms Betty M.,
Yokoyama Jennifer S.,
PiñaEscudero Stefanie D.,
Cochran J. Nicholas,
Matallana Diana L.,
Acosta Daisy,
Allegri Ricardo,
AriasSuárez Bianca P.,
Barra Bernardo,
Behrens Maria Isabel,
Brucki Sonia M. D.,
Busatto Geraldo,
Caramelli Paulo,
CastroSuarez Sheila,
Contreras Valeria,
Custodio Nilton,
Dansilio Sergio,
CruzPuebla Myriam De,
Souza Leonardo Cruz,
Diaz Monica M.,
Duque Lissette,
Farías Gonzalo A.,
Ferreira Sergio T.,
Guimet Nahuel Magrath,
Kmaid Ana,
Lira David,
Lopera Francisco,
Meza Beatriz Mar,
Miotto Eliane C.,
Nitrini Ricardo,
Nuñez Alberto,
O'Neill Santiago,
Ochoa John,
PintadoCaipa Maritza,
Resende Elisa de Paula França,
Risacher Shan,
Rojas Luz Angela,
Sabaj Valentina,
Schilling Lucas,
Sellek Allis F.,
Sosa Ana,
Takada Leonel T.,
Teixeira Antonio L.,
UnauchoPilalumbo Martha,
DuranAniotz Claudia
Publication year - 2023
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12757
Subject(s) - dementia , biomarker , latin americans , medicine , neuroimaging , biomarker discovery , political science , psychiatry , pathology , disease , biology , proteomics , biochemistry , gene , law
Abstract Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts.