Premium
Longitudinal association of apolipoprotein E and sleep with incident dementia
Author(s) -
Palpatzis Eleni,
Bass Nick,
Jones Rebecca,
Mukadam Naaheed
Publication year - 2022
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12439
Subject(s) - hazard ratio , dementia , apolipoprotein e , medicine , longitudinal study , confidence interval , sleep (system call) , proportional hazards model , insomnia , gerontology , psychiatry , disease , pathology , computer science , operating system
Few longitudinal studies have explored the association between apolipoprotein E gene ( APOE ) status, sleep disturbances, and incident dementia among middle‐aged participants. Methods Cox regression analyses explored the association of sleep duration, insomnia, and daytime napping with incident all‐cause dementia and their interaction with APOE genetic risk among 397,777 middle‐aged adults. Results During a median of 10.8 years follow‐up, sleeping more or fewer than 7 hours was associated with a higher dementia risk (hazard ratio [HR] for 5 vs 7 hours: 1.35, 95% confidence interval [CI] 1.11–1.64; HR for 9 vs 7 hours: 1.59; 95% CI 1.37–1.85) as was daytime napping (HR for often/all of the time vs never/rarely: 1.67; 95% CI 1.37–2.03). Stratified analyses revealed that the effects of sleep disturbances were similar across all APOE genetic risk groups. Discussion Short and long sleep duration and daytime napping in middle‐aged individuals are associated with the development of dementia in later life. Sleep duration and quality are important for everyone regardless of their genetic risk by APOE genotype.