Conservation of CGG region in FMR1 gene in mammals | Zendy

Deelen Wout | Zendy; Bakker Cathy | Zendy; Halley Dicky J. J. | Zendy; Oostra Ben A. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Conservation of CGG region in FMR1 gene in mammals

Author(s) -

Deelen Wout,

Bakker Cathy,

Halley Dicky J. J.,

Oostra Ben A.

Publication year - 1994

Publication title -

american journal of medical genetics

Language(s) - English

Resource type - Journals

eISSN - 1096-8628

pISSN - 0148-7299

DOI - 10.1002/ajmg.1320510445

Subject(s) - fragile x syndrome , genetics , fmr1 , biology , chromosomal fragile site , gene , phenotype , x chromosome , trinucleotide repeat expansion , gene duplication , microbiology and biotechnology , fragile x , chromosome , allele

Only two of the fragile sites found in humans (FRAXA and FRAXE) have been associated with a clinical phenotype. In mentally retarded individuals with cytogenetic expression of FRAXA a CGG repeat in the FMR1 gene is amplified. Fragile sites are found in many animal species. We have analyzed the FRAXA region containing the CGG repeat in several different species by PCR amplification. In most mammals this region could be amplified; the number of copies of the repeat is deduced. © 1994 Wiley‐Liss, Inc.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research