Frequencies of UDP‐glucuronosyltransferase 1 ( UGT1A 1) gene promoter polymorphisms among distinct ethnic groups from Brazil | Zendy

Fertrin K.Y. | Zendy; Gonçalves M.S. | Zendy; Saad S.T.O. | Zendy; Costa F.F. | Zendy

Open Access

Frequencies of UDP‐glucuronosyltransferase 1 ( UGT1A 1) gene promoter polymorphisms among distinct ethnic groups from Brazil

Author(s) -

Fertrin K.Y.,

Gonçalves M.S.,

Saad S.T.O.,

Costa F.F.

Publication year - 2002

Publication title -

american journal of medical genetics

Language(s) - English

Resource type - Journals

eISSN - 1096-8628

pISSN - 0148-7299

DOI - 10.1002/ajmg.10209

Subject(s) - genetics , ethnic group , gene , glucuronosyltransferase , biology , polymorphism (computer science) , promoter , allele frequency , allele , gene expression , political science , in vitro , microsome , law

A polymorphism in the promoter region of the UDP‐glucuronosyltransferase 1 ( UGT1A ) gene is associated with Gilbert syndrome (GS), a benign form of mild unconjugated hyperbilirubinemia. We genotyped 157 individuals from Brazil, comprising 71 Caucasians, 54 African‐derived subjects, and 32 Parakanã Indians. Frequencies of the alelle (TA) 7 associated with GS found in this study were 0.324, 0.407, and 0.328, respectively. The genotype frequencies differed significantly between Caucasians and African‐derived individuals. The high frequencies of (TA) 7 polymorphism among the three groups confirm previous data that this polymorphism is very ancient and appears to be distributed throughout the world. © 2002 Wiley‐Liss, Inc.

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