Open AccessInterleukin‐33 is a Novel Immunosuppressor that Protects Cancer Cells from TIL Killing by a Macrophage‐Mediated Shedding Mechanism (Adv. Sci. 21/2021)
Author(s) -
Wu Jing,
Chen Ziqing,
Wickström Stina L.,
Gao Juan,
He Xingkang,
Jing Xu,
Wu Jieyu,
Du Qiqiao,
Yang Muyi,
Chen Yi,
Zhang Dingding,
Yin Xin,
Guo Ziheng,
Jensen Lasse,
Yang Yunlong,
Tao Wei,
Lundqvist Andreas,
Kiessling Rolf,
Cao Yihai
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202170144
Subject(s) - immune system , proteases , cancer cell , mechanism (biology) , cell , macrophage , cancer , melanoma , cancer research , biology , microbiology and biotechnology , chemistry , immunology , in vitro , biochemistry , philosophy , enzyme , genetics , epistemology
Cancer Cells In article number 2101029 by Yihai Cao and co‐workers, it is shown that interleukin‐33 (IL‐33)‐activated macrophages protect melanoma cells from tumor‐infiltrating lymphocytemediated killing. This cover shows a new mechanism of immune T cell‐mediated cancer killing. In the tumor environment, macrophages produce proteases to affect the T cell and cancer cell interaction. The monkey king represents immune T cell, and the bull demon represents cancer cell.