Open AccessImage‐Guided Magnetic Thermoseed Navigation and Tumor Ablation Using a Magnetic Resonance Imaging System
Author(s) -
Baker Rebecca R.,
Payne Christopher,
Yu Yichao,
Mohseni Matin,
Connell John J.,
Lin Fangyu,
Harrison Ian F.,
Southern Paul,
Rudrapatna Umesh S.,
Stuckey Daniel J.,
Kalber Tammy L.,
Siow Bernard,
Thorne Lewis,
Punwani Shonit,
Jones Derek K.,
Emberton Mark,
Pankhurst Quentin A.,
Lythgoe Mark F.
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202105333
Subject(s) - magnetic resonance imaging , interventional magnetic resonance imaging , ablation , scanner , navigation system , biomedical engineering , computer science , image quality , materials science , radiology , medicine , computer vision , artificial intelligence , image (mathematics)
Medical therapies achieve their control at expense to the patient in the form of a range of toxicities, which incur costs and diminish quality of life. Magnetic resonance navigation is an emergent technique that enables image‐guided remote‐control of magnetically labeled therapies and devices in the body, using a magnetic resonance imaging (MRI) system. Minimally INvasive IMage‐guided Ablation (MINIMA), a novel, minimally invasive, MRI‐guided ablation technique, which has the potential to avoid traditional toxicities, is presented. It comprises a thermoseed navigated to a target site using magnetic propulsion gradients generated by an MRI scanner, before inducing localized cell death using an MR‐compatible thermoablative device. The authors demonstrate precise thermoseed imaging and navigation through brain tissue using an MRI system (0.3 mm), and they perform thermoablation in vitro and in vivo within subcutaneous tumors, with the focal ablation volume finely controlled by heating duration. MINIMA is a novel theranostic platform, combining imaging, navigation, and heating to deliver diagnosis and therapy in a single device.