Investigation of Distribution of Heavy Metals between Blood Plasma and Blood Cells

The physiological importance of metals in human organism has been shown by many publications. The toxic doses of metals and their compounds can lead to serious health problems.1–4 Different metals present in the composition of blood can form different complexes with many organic compounds and biomolecules which could be found in the body fluids.5–7 Depending on the concentration of metals in the parts of body, different metal-ligand equilibriums could be established in the system. These changes could cause changes in global bioprocesses, or different clinical symptoms and metabolic stresses in human organism could occur. The distribution of metals between blood plasma and blood cells could represent an important clinical index.8–10 The aim of the present study was to investigate, for the first time to our knowledge, the distribution of heavy metals between blood plasma and cells in the blood samples from the infected by hepatitis C and non-infected patients.