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Tailored Biocompatible Polyurethane‐Poly(ethylene glycol) Hydrogels as a Versatile Nonfouling Biomaterial
Author(s) -
Speidel Alessondra T.,
Chivers Phillip R. A.,
Wood Christopher S.,
Roberts Derrick A.,
Correia Inês P.,
Caravaca April S.,
Chan Yu Kiu Victor,
Hansel Catherine S.,
Heimgärtner Johannes,
Müller Eliane,
Ziesmer Jill,
Sotiriou Georgios A.,
Olofsson Peder S.,
Stevens Molly M.
Publication year - 2022
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202201378
Subject(s) - self healing hydrogels , materials science , biocompatibility , ethylene glycol , polyurethane , biomaterial , protein adsorption , biocompatible material , biomedical engineering , nanotechnology , chemical engineering , polymer , polymer chemistry , composite material , medicine , engineering , metallurgy
Polyurethane‐based hydrogels are relatively inexpensive and mechanically robust biomaterials with ideal properties for various applications, including drug delivery, prosthetics, implant coatings, soft robotics, and tissue engineering. In this report, a simple method is presented for synthesizing and casting biocompatible polyurethane‐poly(ethylene glycol) (PU‐PEG) hydrogels with tunable mechanical properties, nonfouling characteristics, and sustained tolerability as an implantable material or coating. The hydrogels are synthesized via a simple one‐pot method using commercially available precursors and low toxicity solvents and reagents, yielding a consistent and biocompatible gel platform primed for long‐term biomaterial applications. The mechanical and physical properties of the gels are easily controlled by varying the curing concentration, producing networks with complex shear moduli of 0.82–190 kPa, similar to a range of human soft tissues. When evaluated against a mechanically matched poly(dimethylsiloxane) (PDMS) formulation, the PU‐PEG hydrogels demonstrated favorable nonfouling characteristics, including comparable adsorption of plasma proteins (albumin and fibrinogen) and significantly reduced cellular adhesion. Moreover, preliminary murine implant studies reveal a mild foreign body response after 41 days. Due to the tunable mechanical properties, excellent biocompatibility, and sustained in vivo tolerability of these hydrogels, it is proposed that this method offers a simplified platform for fabricating soft PU‐based biomaterials for a variety of applications.