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The Importance of Interfaces in Multi‐Material Biofabricated Tissue Structures
Author(s) -
Viola Martina,
Piluso Susanna,
Groll Jürgen,
Vermonden Tina,
Malda Jos,
Castilho Miguel
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202101021
Subject(s) - biofabrication , nanotechnology , materials science , interface (matter) , biological materials , computer science , biochemical engineering , tissue engineering , engineering , biomedical engineering , composite material , capillary number , capillary action
Biofabrication exploits additive manufacturing techniques for creating 3D structures with a precise geometry that aim to mimic a physiological cellular environment and to develop the growth of native tissues. The most recent approaches of 3D biofabrication integrate multiple technologies into a single biofabrication platform combining different materials within different length scales to achieve improved construct functionality. However, the importance of interfaces between the different material phases, has not been adequately explored. This is known to determine material's interaction and ultimately mechanical and biological performance of biofabricated parts. In this review, this gap is bridged by critically examining the interface between different material phases in (bio)fabricated structures, with a particular focus on how interfacial interactions can compromise or define the mechanical (and biological) properties of the engineered structures. It is believed that the importance of interfacial properties between the different constituents of a composite material, deserves particular attention in its role in modulating the final characteristics of 3D tissue‐like structures.