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High‐Performance Magnetic FePt (L1 0 ) Surface Microrollers Towards Medical Imaging‐Guided Endovascular Delivery Applications
Author(s) -
Bozuyuk Ugur,
Suadiye Eylul,
Aghakhani Amirreza,
Dogan Nihal Olcay,
Lazovic Jelena,
Tiryaki Mehmet Efe,
Schneider Martina,
Karacakol Alp Can,
Demir Sinan Ozgun,
Richter Gunther,
Sitti Metin
Publication year - 2022
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202109741
Subject(s) - biocompatibility , materials science , magnetic resonance imaging , biomedical engineering , coating , nanotechnology , medical imaging , computer science , radiology , medicine , artificial intelligence , metallurgy
Controlled microrobotic navigation in the vascular system can revolutionize minimally invasive medical applications, such as targeted drug and gene delivery. Magnetically controlled surface microrollers have emerged as a promising microrobotic platform for controlled navigation in the circulatory system. Locomotion of micrororollers in strong flow velocities is a highly challenging task, which requires magnetic materials having strong magnetic actuation properties while being biocompatible. The L1 0 ‐FePt magnetic coating can achieve such requirements. Therefore, such coating has been integrated into 8 µ m‐diameter surface microrollers and investigated the medical potential of the system from magnetic locomotion performance, biocompatibility, and medical imaging perspectives. The FePt coating significantly advanced the magnetic performance and biocompatibility of the microrollers compared to a previously used magnetic material, nickel. The FePt coating also allowed multimodal imaging of microrollers in magnetic resonance and photoacoustic imaging in ex vivo settings without additional contrast agents. Finally, FePt‐coated microrollers showed upstream locomotion ability against 4.5 cm s −1 average flow velocity with real‐time photoacoustic imaging, demonstrating the navigation control potential of microrollers in the circulatory system for future in vivo applications. Overall, L1 0 ‐FePt is conceived as the key material for image‐guided propulsion in the vascular system to perform future targeted medical interventions.