An Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo | Zendy

Proctor Christopher M. | Zendy; Uguz Ilke | Zendy; Slezia Andrea | Zendy; Curto Vincenzo | Zendy; Inal Sahika | Zendy; Williamson Adam | Zendy; Malliaras George G. | Zendy

Open Access

An Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo

Author(s) -

Proctor Christopher M.,

Uguz Ilke,

Slezia Andrea,

Curto Vincenzo,

Inal Sahika,

Williamson Adam,

Malliaras George G.

Publication year - 2019

Publication title -

advanced biosystems

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.153

H-Index - 18

ISSN - 2366-7478

DOI - 10.1002/adbi.201800270

Subject(s) - drug delivery , electrocorticography , microfluidics , biomedical engineering , in vivo , neural activity , drug , computer science , nanotechnology , neuroscience , materials science , medicine , electroencephalography , pharmacology , biology , microbiology and biotechnology

The challenge of treating neurological disorders has motivated the development of implantable devices that can deliver treatment when and where it is needed. This study presents a novel brain implant capable of electrophoretically delivering drugs and recording local neural activity on the surface of the brain. The drug delivery is made possible by the integration of a microfluidic ion pump (µFIP) into a conformable electrocorticography (ECoG) device with recording cites embedded next to the drug delivery outlets. The µFIP ECoG device can deliver a high capacity of several biologically important cationic species on demand. The therapeutic potential of the device is demonstrated by using it to deliver neurotransmitters in a rodent model while simultaneously recording local neural activity. These developments represent a significant step forward for cortical drug‐delivery systems.

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