Hamster Model of Leptospirosis | Zendy

Haake David A. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Hamster Model of Leptospirosis

Author(s) -

Haake David A.

Publication year - 2006

Publication title -

current protocols in microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.813

H-Index - 35

eISSN - 1934-8533

pISSN - 1934-8525

DOI - 10.1002/9780471729259.mc12e02s02

Subject(s) - hamster , leptospirosis , biology , leptospira , mesocricetus , virulence , microbiology and biotechnology , animal model , golden hamster , virology , veterinary medicine , genetics , medicine , gene , endocrinology

This unit describes the techniques involved in the hamster model of leptospirosis. Hamsters are exquisitely susceptible to infection with pathogenic Leptospira species. The LD 50 of virulent Leptospira l strains by intraperitoneal inoculation of 3‐ to 4‐week‐old hamsters is as low as a single organism. The pathogenesis of severe leptospirosis in the hamster is a model of accidental infections observed in nature in many mammals, including humans. Animal husbandry issues and the reproducibility of the hamster model make it the animal model of choice for Leptospira l vaccine and antibiotic treatment studies.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research