Open AccessHollow‐Fiber Methodology for Pharmacokinetic/Pharmacodynamic Studies of Antimalarial Compounds
Author(s) -
Caton Emily,
Nenortas Elizabeth,
Bakshi Rahul P.,
Shapiro Theresa A.
Publication year - 2016
Publication title -
current protocols in chemical biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.503
H-Index - 14
ISSN - 2160-4762
DOI - 10.1002/9780470559277.ch150194
Subject(s) - pharmacodynamics , plasmodium falciparum , pharmacokinetics , pharmacology , dosing , drug development , drug , in vitro , in vivo , computational biology , medicine , biology , microbiology and biotechnology , malaria , biochemistry , immunology
Knowledge of pharmacokinetic/pharmacodynamic (PK/PD) relationships can enhance the speed and economy of drug development by enabling informed and rational decisions at every step, from lead selection to clinical dosing. For anti‐infective agents in particular, dynamic in vitro hollow‐fiber cartridge experiments permit exquisite control of kinetic parameters and the study of their consequent impact on pharmacodynamic efficacy. Such information is of great interest for the cost‐restricted but much‐needed development of new antimalarial drugs, especially since the major human pathogen Plasmodium falciparum can be cultivated in vitro but is not readily available in animal models. This protocol describes the materials and procedures for determining the PK/PD relationships of antimalarial compounds. © 2016 by John Wiley & Sons, Inc.