Open AccessLaser light scattering study of the degradation of poly(sebacic anhydride) nanoparticles
Author(s) -
Fu Jie,
Wu Chi
Publication year - 2001
Publication title -
journal of polymer science part b: polymer physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.65
H-Index - 145
eISSN - 1099-0488
pISSN - 0887-6266
DOI - 10.1002/1099-0488(20010315)39:6<703::aid-polb1044>3.0.co;2-b
Subject(s) - sebacic acid , nanoparticle , degradation (telecommunications) , polymer , materials science , dynamic light scattering , polymer chemistry , chemical engineering , reaction rate constant , chemistry , composite material , nanotechnology , kinetics , telecommunications , physics , quantum mechanics , computer science , engineering
Poly(sebacic anhydride) (PSA) is biocompatible and degradable in basic media. We micronized this water‐insoluble polymer into stable polymeric nanoparticles via a microphase inversion. Such PSA nanoparticles degraded much faster than bulk PSA. The influence of the surfactant, temperature, and pH on the degradation of the PSA nanoparticles was investigated by a combination of static and dynamic laser light scattering. Under each condition, the degradation rate was nearly constant up to a 75% weight loss; that is, the degradation was close to zero‐order. The degradation rate increased with the pH and temperature. Biomedical applications of such PSA nanoparticles are suggested. © 2001 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 39: 703–708, 2001