Open AccessDevelopmental seizures induced by common early‐life insults: Short‐ and long‐term effects on seizure susceptibility
Author(s) -
Jensen Frances E.,
Baram Tallie Z.
Publication year - 2000
Publication title -
mental retardation and developmental disabilities research reviews
Language(s) - English
Resource type - Journals
eISSN - 1098-2779
pISSN - 1080-4013
DOI - 10.1002/1098-2779(2000)6:4<253::aid-mrdd4>3.0.co;2-p
Subject(s) - citation , psychology , medicine , gerontology , neuroscience , pediatrics , library science , computer science
The immature brain is highly susceptible to seizures induced by a variety of insults, including hypoxia, fever, and trauma. Unlike early life epilepsy associated with congenital dysplasias or genetic abnormalities, insults induce a hyperexcitable state in a previously normal brain. Here we evaluate the epileptogenic effects of seizure‐inducing stimuli on the developing brain, and the age and regional specificity of these effects. MRDD Research Reviews 2000;6:253–257. © 2000 Wiley‐Liss, Inc.