Open AccessUsing the Structure‐Function Linkage Database to Characterize Functional Domains in Enzymes
Author(s) -
Brown Shoshana,
Babbitt Patricia
Publication year - 2014
Publication title -
current protocols in bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.535
H-Index - 57
eISSN - 1934-340X
pISSN - 1934-3396
DOI - 10.1002/0471250953.bi0210s48
Subject(s) - linkage (software) , database , function (biology) , computational biology , computer science , biology , genetics , gene
The Structure-Function Linkage Database (SFLD; http://sfld.rbvi.ucsf.edu/) is a Web-accessible database designed to link enzyme sequence, structure, and functional information. This unit describes the protocols by which a user may query the database to predict the function of uncharacterized enzymes and to correct misannotated functional assignments. The information in this unit is especially useful in helping a user discriminate functional capabilities of a sequence that is only distantly related to characterized sequences in publicly available databases.