Open AccessDextran Sulfate Sodium (DSS)‐Induced Colitis in Mice
Author(s) -
Chassaing Benoit,
Aitken Jesse D.,
Malleshappa Madhu,
VijayKumar Matam
Publication year - 2014
Publication title -
current protocols in immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.618
H-Index - 43
eISSN - 1934-368X
pISSN - 1934-3671
DOI - 10.1002/0471142735.im1525s104
Subject(s) - ulcerative colitis , colitis , inflammatory bowel disease , immunology , inflammatory bowel diseases , medicine , disease , pathogenesis , pathology
Inflammatory bowel diseases (IBD), mainly comprising ulcerative colitis and Crohn's Disease, are complex and multifactorial diseases with unknown etiology. For the past 20 years, to study human IBD mechanistically, a number of murine models of colitis have been developed. These models are indispensable tools to decipher underlying mechanisms of IBD pathogenesis as well as to evaluate a number of potential therapeutics. Among various chemically induced colitis models, the dextran sulfate sodium (DSS)‐induced colitis model is widely used because of its simplicity and many similarities with human ulcerative colitis. This model has both advantages and disadvantages that must be considered when employed. This protocol describes the DSS‐induced colitis model, focusing on details and factors that could affect DSS‐induced pathology. Curr. Protoc. Immunol . 104:15.25.1‐15.25.14. © 2014 by John Wiley & Sons, Inc.