Open AccessExamining Object Location and Object Recognition Memory in Mice
Author(s) -
VogelCiernia Annie,
Wood Marcelo A.
Publication year - 2014
Publication title -
current protocols in neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 40
eISSN - 1934-8576
pISSN - 1934-8584
DOI - 10.1002/0471142301.ns0831s69
Subject(s) - novelty , object (grammar) , computer science , task (project management) , artificial intelligence , memory model , cognitive neuroscience of visual object recognition , machine learning , psychology , computer hardware , social psychology , management , shared memory , economics
This unit is designed to provide sufficient instruction for the setup and execution of tests for object location and object recognition in adult mice. This task is ideally suited for the study of a variety of mouse models that examine disease mechanisms and novel therapeutic targets. By altering several key parameters, the experimenter can investigate short‐term or long‐term memory and look for either memory impairments or enhancements. Object location and object recognition memory tasks rely on a rodent's innate preference for novelty, and can be conducted sequentially in the same cohort of animals. These two tasks avoid the inherent stress induced with other common measures of rodent memory such as fear conditioning and the Morris water maze. This protocol covers detailed instructions on conducting both tasks, as well as key points concerning data collection, analysis, and interpretation. Curr. Protoc. Neurosci . 69:8.31.1‐8.31.17. © 2014 by John Wiley & Sons, Inc.