Open AccessOverview of Transgenic Glioblastoma and Oligoastrocytoma CNS Models and Their Utility in Drug Discovery
Author(s) -
Chen Fuyi,
Becker Albert,
LoTurco Joseph
Publication year - 2016
Publication title -
current protocols in pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.893
H-Index - 26
eISSN - 1934-8290
pISSN - 1934-8282
DOI - 10.1002/0471141755.ph1437s72
Subject(s) - drug discovery , electroporation , central nervous system , biology , in utero , neuroscience , glioblastoma , transgene , computational biology , cancer research , bioinformatics , genetics , fetus , gene , pregnancy
Many animal models have been developed to investigate the sources of central nervous system (CNS) tumor heterogeneity. Reviewed in this unit is a recently developed CNS tumor model using the piggyBac transposon system delivered by in utero electroporation, in which sources of tumor heterogeneity can be conveniently studied. Their applications for studying CNS tumors and drug discovery are also reviewed. © 2016 by John Wiley & Sons, Inc.