Development and Validation of a Comprehensive Model to Estimate Early Allograft Failure Among Patients Requiring Early Liver Retransplant | Zendy

A.W. Avolio | Zendy; Antonio Franco | Zendy; Andrea Schlegel | Zendy; Quirino Lai | Zendy; S Meli | Zendy; Patrizia Burra | Zendy; Damiano Patrono | Zendy; Matteo Ravaioli | Zendy; Daniela Bassi | Zendy; Fabio Ferla | Zendy; Duilio Pagano | Zendy; Paola Violi | Zendy; Stefania Camagni | Zendy; Daniele Dondossola | Zendy; Roberto Montalti | Zendy; Wasfi Alrawashdeh | Zendy; Alessandro Vitale | Zendy; Luciana Teofili | Zendy; Gabriele Spoletini | Zendy; Paolo Magistri | Zendy; Marco Bongini | Zendy; Massimo Rossi | Zendy; Vincenzo Mazzaferro | Zendy; Fabrizio Di Benedetto | Zendy; John Hammond | Zendy; Marco Vivarelli | Zendy; S. Agnes | Zendy; M. Colledan | Zendy; Amedeo Carraro | Zendy; Matteo Cescon | Zendy; Luciano De Carlis | Zendy; L. Caccamo | Zendy; Salvatore Gruttadauria | Zendy; Paolo Muiesan | Zendy; Umberto Cillo | Zendy; Renato Romagnoli | Zendy; Paolo De Simone | Zendy

Open Access

Development and Validation of a Comprehensive Model to Estimate Early Allograft Failure Among Patients Requiring Early Liver Retransplant

Author(s) -

A.W. Avolio,

Antonio Franco,

Andrea Schlegel,

Quirino Lai,

S Meli,

Patrizia Burra,

Damiano Patrono,

Matteo Ravaioli,

Daniela Bassi,

Fabio Ferla,

Duilio Pagano,

Paola Violi,

Stefania Camagni,

Daniele Dondossola,

Roberto Montalti,

Wasfi Alrawashdeh,

Alessandro Vitale,

Luciana Teofili,

Gabriele Spoletini,

Paolo Magistri,

Marco Bongini,

Massimo Rossi,

Vincenzo Mazzaferro,

Fabrizio Di Benedetto,

John Hammond,

Marco Vivarelli,

S. Agnes,

M. Colledan,

Amedeo Carraro,

Matteo Cescon,

Luciano De Carlis,

L. Caccamo,

Salvatore Gruttadauria,

Paolo Muiesan,

Umberto Cillo,

Renato Romagnoli,

Paolo De Simone

Publication year - 2020

Publication title -

jama surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.757

H-Index - 176

eISSN - 2168-6262

pISSN - 2168-6254

DOI - 10.1001/jamasurg.2020.4095

Subject(s) - medicine , liver transplantation , incidence (geometry) , retrospective cohort study , cumulative incidence , transplantation , population , surgery , physics , environmental health , optics

Key Points Question Can the individual risk estimation for early allograft failure (EAF) be improved in view of liver retransplant? Findings In this multicenter cohort study investigating the association between donor-recipient factors and EAF, a novel Early Allograft Failure Simplified Estimation (EASE) score was developed. The score includes Model for End-stage Liver Disease score, transfused packed red blood cells, and hepatic vessel early thrombosis as well as transaminases, platelet, and bilirubin kinetics as variables on day 10 after transplant. The EASE score outperformed previous model scores, estimating EAF risk with 87% accuracy on day 90 after transplant; EASE was developed on a multicenter Italian database (1609 recipients) and validated on an external UK database (538 recipients). Meaning In this study, the EASE score rated the EAF risk (0%-100%) and identified cases at unsustainable risk to be listed for retransplant.

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