Development and Validation of a Prediction Model for Mortality and Adverse Outcomes Among Patients With Peripheral Eosinopenia on Admission for Clostridium difficile Infection | Zendy

Audrey S. Kulaylat | Zendy; Erica L. Buonomo | Zendy; Kenneth W. Scully | Zendy; Christopher S. Hollenbeak | Zendy; Heather Cook | Zendy; William A. Petri | Zendy; David B. Stewart | Zendy

Open Access

Development and Validation of a Prediction Model for Mortality and Adverse Outcomes Among Patients With Peripheral Eosinopenia on Admission for Clostridium difficile Infection

Author(s) -

Audrey S. Kulaylat,

Erica L. Buonomo,

Kenneth W. Scully,

Christopher S. Hollenbeak,

Heather Cook,

William A. Petri,

David B. Stewart

Publication year - 2018

Publication title -

jama surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.757

H-Index - 176

eISSN - 2168-6262

pISSN - 2168-6254

DOI - 10.1001/jamasurg.2018.3174

Subject(s) - medicine , clostridium difficile , eosinopenia , cohort , odds ratio , eosinophil , logistic regression , colectomy , emergency medicine , disease , ulcerative colitis , microbiology and biotechnology , biology , antibiotics , asthma

Recent evidence from an animal model suggests that peripheral loss of eosinophils in Clostridium difficile infection (CDI) is associated with severe disease. The ability to identify high-risk patients with CDI as early as the time of admission could improve outcomes by guiding management decisions.

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