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Effect of Airway Pressure Release Ventilation on Dynamic Alveolar Heterogeneity
Author(s) -
Michaela KollischSingule,
Sumeet Jain,
Penny Andrews,
Bradford J. Smith,
Katharine L. Hamlington,
Shreyas Roy,
David DiStefano,
Emily Nuss,
Joshua Satalin,
Qinghe Meng,
William Marx,
Jason H. T. Bates,
Louis A. Gatto,
Gary F. Nieman,
Nader M. Habashi
Publication year - 2015
Publication title -
jama surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.757
H-Index - 176
eISSN - 2168-6262
pISSN - 2168-6254
DOI - 10.1001/jamasurg.2015.2683
Subject(s) - medicine , tidal volume , pulmonary surfactant , ventilation (architecture) , anesthesia , mechanical ventilation , lung , positive end expiratory pressure , airway , mean airway pressure , respiratory system , chemistry , mechanical engineering , biochemistry , engineering
Ventilator-induced lung injury may arise from heterogeneous lung microanatomy, whereby some alveoli remain collapsed throughout the breath cycle while their more compliant or surfactant-replete neighbors become overdistended, and this is called dynamic alveolar heterogeneity.

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