Assessment of Striatal Dopamine Transporter Binding in Individuals With Major Depressive Disorder | Zendy

Diego A. Pizzagalli | Zendy; Sabina Berretta | Zendy; Dustin Wooten | Zendy; Franziska Goer | Zendy; Kanoelani Pilobello | Zendy; Poornima Kumar | Zendy; Laura Murray | Zendy; Miranda Beltzer | Zendy; Anne BoyerBoiteau | Zendy; Nathanial Alpert | Zendy; Georges El Fakhri | Zendy; Naguib Mechawar | Zendy; Gordana Vitaliano | Zendy; Gustavo Turecki | Zendy; Marc D. Normandin | Zendy

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Assessment of Striatal Dopamine Transporter Binding in Individuals With Major Depressive Disorder

Author(s) -

Diego A. Pizzagalli,

Sabina Berretta,

Dustin Wooten,

Franziska Goer,

Kanoelani Pilobello,

Poornima Kumar,

Laura Murray,

Miranda Beltzer,

Anne BoyerBoiteau,

Nathanial Alpert,

Georges El Fakhri,

Naguib Mechawar,

Gordana Vitaliano,

Gustavo Turecki,

Marc D. Normandin

Publication year - 2019

Publication title -

jama psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.531

H-Index - 365

eISSN - 2168-6238

pISSN - 2168-622X

DOI - 10.1001/jamapsychiatry.2019.0801

Subject(s) - dopamine transporter , major depressive disorder , medicine , positron emission tomography , psychology , psychiatry , dopamine , depression (economics) , oncology , endocrinology , neuroscience , mood , dopaminergic , economics , macroeconomics

Major depressive disorder (MDD) might involve dopamine (DA) reductions. The DA transporter (DAT) regulates DA clearance and neurotransmission and is sensitive to DA levels, with preclinical studies (including those involving inescapable stressors) showing that DAT density decreases when DA signaling is reduced. Despite preclinical data, evidence of reduced DAT in MDD is inconclusive.

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