Monoamine Oxidase B Total Distribution Volume in the Prefrontal Cortex of Major Depressive Disorder | Zendy

Sho Moriguchi | Zendy; Alan A. Wilson | Zendy; Laura Miler | Zendy; Pablo Rusjan | Zendy; Neil Vasdev | Zendy; Stephen J. Kish | Zendy; Grażyna Rajkowska | Zendy; Junming Wang | Zendy; Michael Bagby | Zendy; Romina Mizrahi | Zendy; Ben Varughese | Zendy; Sylvain Houle | Zendy; Jeffrey H. Meyer | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Monoamine Oxidase B Total Distribution Volume in the Prefrontal Cortex of Major Depressive Disorder

Author(s) -

Sho Moriguchi,

Alan A. Wilson,

Laura Miler,

Pablo Rusjan,

Neil Vasdev,

Stephen J. Kish,

Grażyna Rajkowska,

Junming Wang,

Michael Bagby,

Romina Mizrahi,

Ben Varughese,

Sylvain Houle,

Jeffrey H. Meyer

Publication year - 2019

Publication title -

jama psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.531

H-Index - 365

eISSN - 2168-6238

pISSN - 2168-622X

DOI - 10.1001/jamapsychiatry.2019.0044

Subject(s) - monoamine oxidase b , prefrontal cortex , medicine , monoamine oxidase a , positron emission tomography , psychiatry , psychology , monoamine oxidase , nuclear medicine , serotonin , nuclear magnetic resonance , physics , receptor , cognition , enzyme

Monoamine oxidase B (MAO-B) is an important, high-density enzyme in the brain that generates oxidative stress by hydrogen peroxide production, alters mitochondrial function, and metabolizes nonserotonergic monoamines. Recent advances in positron emission tomography radioligand development for MAO-B in humans enable highly quantitative measurement of MAO-B distribution volume (MAO-B VT), an index of MAO-B density. To date, this is the first investigation of MAO-B in the brain of major depressive disorder that evaluates regions beyond the raphe and amygdala.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research