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Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults
Author(s) -
Karmel W. Choi,
ChiaYen Chen,
Murray B. Stein,
Yann C. Klimentidis,
Min-Jung Wang,
Karestan C. Koenen,
Jordan W. Smoller
Publication year - 2019
Publication title -
jama psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.531
H-Index - 365
eISSN - 2168-6238
pISSN - 2168-622X
DOI - 10.1001/jamapsychiatry.2018.4175
Subject(s) - mendelian randomization , major depressive disorder , genome wide association study , pleiotropy , depression (economics) , causal inference , medicine , psychology , clinical psychology , genetics , single nucleotide polymorphism , biology , genetic variants , genotype , macroeconomics , pathology , mood , economics , phenotype , gene
Increasing evidence shows that physical activity is associated with reduced risk for depression, pointing to a potential modifiable target for prevention. However, the causality and direction of this association are not clear; physical activity may protect against depression, and/or depression may result in decreased physical activity.

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