Mapping the Heterogeneous Phenotype of Schizophrenia and Bipolar Disorder Using Normative Models | Zendy

Thomas Wolfers | Zendy; Nhat Trung Doan | Zendy; Tobias Kaufmann | Zendy; Dag Alnæs | Zendy; Torgeir Moberget | Zendy; Ingrid Agartz | Zendy; Jan K. Buitelaar | Zendy; Torill Ueland | Zendy; Ingrid Melle | Zendy; Barbara Franke | Zendy; Ole A. Andreassen | Zendy; Christian F. Beckmann | Zendy; Lars T. Westlye | Zendy; André F. Marquand | Zendy

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Mapping the Heterogeneous Phenotype of Schizophrenia and Bipolar Disorder Using Normative Models

Author(s) -

Thomas Wolfers,

Nhat Trung Doan,

Tobias Kaufmann,

Dag Alnæs,

Torgeir Moberget,

Ingrid Agartz,

Jan K. Buitelaar,

Torill Ueland,

Ingrid Melle,

Barbara Franke,

Ole A. Andreassen,

Christian F. Beckmann,

Lars T. Westlye,

André F. Marquand

Publication year - 2018

Publication title -

jama psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.531

H-Index - 365

eISSN - 2168-6238

pISSN - 2168-622X

DOI - 10.1001/jamapsychiatry.2018.2467

Subject(s) - bipolar disorder , schizophrenia (object oriented programming) , psychosis , psychology , bipolar i disorder , population , psychiatry , clinical psychology , medicine , mania , mood , environmental health

Schizophrenia and bipolar disorder are severe and complex brain disorders characterized by substantial clinical and biological heterogeneity. However, case-control studies often ignore such heterogeneity through their focus on the average patient, which may be the core reason for a lack of robust biomarkers indicative of an individual's treatment response and outcome.

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