Transdiagnostic Symptom Clusters and Associations With Brain, Behavior, and Daily Function in Mood, Anxiety, and Trauma Disorders | Zendy

Katherine A. Grisanzio | Zendy; Andrea GoldsteinPiekarski | Zendy; Michelle Yuyun Wang | Zendy; Abdullah P. Rashed Ahmed | Zendy; Zoe Samara | Zendy; Leanne M. Williams | Zendy

Open Access

Transdiagnostic Symptom Clusters and Associations With Brain, Behavior, and Daily Function in Mood, Anxiety, and Trauma Disorders

Author(s) -

Katherine A. Grisanzio,

Andrea GoldsteinPiekarski,

Michelle Yuyun Wang,

Abdullah P. Rashed Ahmed,

Zoe Samara,

Leanne M. Williams

Publication year - 2017

Publication title -

jama psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.531

H-Index - 365

eISSN - 2168-6238

pISSN - 2168-622X

DOI - 10.1001/jamapsychiatry.2017.3951

Subject(s) - anxiety , panic disorder , mood , mood disorders , generalizability theory , clinical psychology , psychology , specific phobia , cognition , psychiatry , developmental psychology

The symptoms that define mood, anxiety, and trauma disorders are highly overlapping across disorders and heterogeneous within disorders. It is unknown whether coherent subtypes exist that span multiple diagnoses and are expressed functionally (in underlying cognition and brain function) and clinically (in daily function). The identification of cohesive subtypes would help disentangle the symptom overlap in our current diagnoses and serve as a tool for tailoring treatment choices.

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