Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder | Zendy

Azmeraw T. Amare | Zendy; Klaus Oliver Schubert | Zendy; Liping Hou | Zendy; Scott Clark | Zendy; Sergi Papiol | Zendy; Urs Heilbronner | Zendy; Franziska Degenhardt | Zendy; Fasil TekolaAyele | Zendy; YiHsiang Hsu | Zendy; Tatyana Shekhtman | Zendy; Mazda Adli | Zendy; Nirmala Akula | Zendy; Kazufumi Akiyama | Zendy; Raffaella Ardau | Zendy; Bárbara Arias | Zendy; JeanMichel Aubry | Zendy; Lena Backlund | Zendy; Abesh Kumar Bhattacharjee | Zendy; Frank Bellivier | Zendy; Antonio Benabarre | Zendy; Susanne Bengesser | Zendy; Joanna M. Biernacka | Zendy; Armin Birner | Zendy; Clara BrichantPetitjean | Zendy; Pablo Cervantes | Zendy; HsiChung Chen | Zendy; Caterina Chillotti | Zendy; Sven Cichon | Zendy; Cristiana Cruceanu | Zendy; Piotr M. Czerski | Zendy; Nina Dalkner | Zendy; Alexandre Dayer | Zendy; Maria Del Zompo | Zendy; J. Raymond DePaulo | Zendy; Bruno Étain | Zendy; Peter Falkai | Zendy; Andreas J. Forstner | Zendy; Louise Frisén | Zendy; Mark A. Frye | Zendy; Janice M. Fullerton | Zendy; Sébastien Gard | Zendy; Julie Garnham | Zendy; Fernando S. Goes | Zendy; Maria GrigoroiuSerbânescu | Zendy; Paul Grof | Zendy; Ryota Hashimoto | Zendy; Joanna Hauser | Zendy; Stefan Herms | Zendy; Per Hoffmann | Zendy; Andrea Hofmann | Zendy; Stéphane Jamain | Zendy; Esther Jiménez | Zendy; JeanPierre Kahn | Zendy; Layla Kassem | Zendy; PoHsiu Kuo | Zendy; Tadafumi Kato | Zendy; John R. Kelsoe | Zendy; Sarah KittelSchneider | Zendy; Sebastian Kliwicki | Zendy; Barbara König | Zendy; Ichiro Kusumi | Zendy; Gonzalo Laje | Zendy; Mikael Landén | Zendy; Catharina Lavebratt | Zendy; Marion Leboyer | Zendy; Susan G. Leckband | Zendy; Alfonso Tortorella | Zendy; Mirko Manchia | Zendy; Lina Martinsson | Zendy; Michael J. McCarthy | Zendy; Susan L. McElroy | Zendy; Francesc Colom | Zendy; Marina Mitjans | Zendy; Francis M. Mondimore | Zendy; Palmiero Monteleone | Zendy; Caroline M. Nievergelt | Zendy; Markus M. Nöthen | Zendy; Tomáš Novák | Zendy; Claire O’Donovan | Zendy; Norio Ozaki | Zendy; Urban Ösby | Zendy; Andrea Pfennig | Zendy; James B. Potash | Zendy; Andreas Reif | Zendy; Eva Z. Reininghaus | Zendy; Guy A. Rouleau | Zendy; Janusz Rybakowski | Zendy; Martin Schalling | Zendy; Peter R. Schofield | Zendy; Barbara Schweizer | Zendy; Giovanni Severino | Zendy; Paul D. Shilling | Zendy; Katzutaka Shimoda | Zendy; Christian Simhandl | Zendy; Claire Slaney | Zendy; Alessio Squassina | Zendy; Thomas Stamm | Zendy; Pavla Stopková | Zendy; Mario Maj | Zendy; Gustavo Turecki | Zendy; Eduard Vieta | Zendy; Julia Volkert | Zendy; Stephanie H. Witt | Zendy; A. Jordan Wright | Zendy; Peter P. Zandi | Zendy; Philip B. Mitchell | Zendy; Michael Bauer | Zendy; Martin Alda | Zendy; Marcella Rietschel | Zendy; Francis J. McMahon | Zendy; Thomas G. Schulze | Zendy; Bernhard T. Baune | Zendy

Open Access

Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder

Author(s) -

Azmeraw T. Amare,

Klaus Oliver Schubert,

Liping Hou,

Scott Clark,

Sergi Papiol,

Urs Heilbronner,

Franziska Degenhardt,

Fasil TekolaAyele,

YiHsiang Hsu,

Tatyana Shekhtman,

Mazda Adli,

Nirmala Akula,

Kazufumi Akiyama,

Raffaella Ardau,

Bárbara Arias,

JeanMichel Aubry,

Lena Backlund,

Abesh Kumar Bhattacharjee,

Frank Bellivier,

Antonio Benabarre,

Susanne Bengesser,

Joanna M. Biernacka,

Armin Birner,

Clara BrichantPetitjean,

Pablo Cervantes,

HsiChung Chen,

Caterina Chillotti,

Sven Cichon,

Cristiana Cruceanu,

Piotr M. Czerski,

Nina Dalkner,

Alexandre Dayer,

Maria Del Zompo,

J. Raymond DePaulo,

Bruno Étain,

Peter Falkai,

Andreas J. Forstner,

Louise Frisén,

Mark A. Frye,

Janice M. Fullerton,

Sébastien Gard,

Julie Garnham,

Fernando S. Goes,

Maria GrigoroiuSerbânescu,

Paul Grof,

Ryota Hashimoto,

Joanna Hauser,

Stefan Herms,

Per Hoffmann,

Andrea Hofmann,

Stéphane Jamain,

Esther Jiménez,

JeanPierre Kahn,

Layla Kassem,

PoHsiu Kuo,

Tadafumi Kato,

John R. Kelsoe,

Sarah KittelSchneider,

Sebastian Kliwicki,

Barbara König,

Ichiro Kusumi,

Gonzalo Laje,

Mikael Landén,

Catharina Lavebratt,

Marion Leboyer,

Susan G. Leckband,

Alfonso Tortorella,

Mirko Manchia,

Lina Martinsson,

Michael J. McCarthy,

Susan L. McElroy,

Francesc Colom,

Marina Mitjans,

Francis M. Mondimore,

Palmiero Monteleone,

Caroline M. Nievergelt,

Markus M. Nöthen,

Tomáš Novák,

Claire O’Donovan,

Norio Ozaki,

Urban Ösby,

Andrea Pfennig,

James B. Potash,

Andreas Reif,

Eva Z. Reininghaus,

Guy A. Rouleau,

Janusz Rybakowski,

Martin Schalling,

Peter R. Schofield,

Barbara Schweizer,

Giovanni Severino,

Paul D. Shilling,

Katzutaka Shimoda,

Christian Simhandl,

Claire Slaney,

Alessio Squassina,

Thomas Stamm,

Pavla Stopková,

Mario Maj,

Gustavo Turecki,

Eduard Vieta,

Julia Volkert,

Stephanie H. Witt,

A. Jordan Wright,

Peter P. Zandi,

Philip B. Mitchell,

Michael Bauer,

Martin Alda,

Marcella Rietschel,

Francis J. McMahon,

Thomas G. Schulze,

Bernhard T. Baune

Publication year - 2017

Publication title -

jama psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.531

H-Index - 365

eISSN - 2168-6238

pISSN - 2168-622X

DOI - 10.1001/jamapsychiatry.2017.3433

Subject(s) - bipolar disorder , genome wide association study , genetic association , medicine , lithium (medication) , bipolar ii disorder , mood , mood disorders , mood stabilizer , major depressive disorder , schizophrenia (object oriented programming) , psychology , oncology , clinical psychology , psychiatry , genotype , genetics , biology , single nucleotide polymorphism , anxiety , gene

Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30%. Biological response markers are lacking. Genetic factors are thought to mediate treatment response to lithium, and there is a previously reported genetic overlap between BPAD and schizophrenia (SCZ).

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