Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence | Zendy

Allan M. Andersen | Zendy; Robert H. Pietrzak | Zendy; Henry R. Kranzler | Zendy; Li Ma | Zendy; Hang Zhou | Zendy; Xiaoming Liu | Zendy; John R. Kramer | Zendy; Samuel Kuperman | Zendy; Howard J. Edenberg | Zendy; John I. Nürnberger | Zendy; John P. Rice | Zendy; Jay A. Tischfield | Zendy; Alison Goate | Zendy; Tatiana Foroud | Zendy; Jacquelyn L. Meyers | Zendy; Bernice Porjesz | Zendy; Danielle M. Dick | Zendy; Victor Hesselbrock | Zendy; Eric Boerwinkle | Zendy; Steven M. Southwick | Zendy; John H. Krystal | Zendy; Myrna M. Weissman | Zendy; Douglas F. Levinson | Zendy; James B. Potash | Zendy; Joel Gelernter | Zendy; Shizhong Han | Zendy

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Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence

Author(s) -

Allan M. Andersen,

Robert H. Pietrzak,

Henry R. Kranzler,

Li Ma,

Hang Zhou,

Xiaoming Liu,

John R. Kramer,

Samuel Kuperman,

Howard J. Edenberg,

John I. Nürnberger,

John P. Rice,

Jay A. Tischfield,

Alison Goate,

Tatiana Foroud,

Jacquelyn L. Meyers,

Bernice Porjesz,

Danielle M. Dick,

Victor Hesselbrock,

Eric Boerwinkle,

Steven M. Southwick,

John H. Krystal,

Myrna M. Weissman,

Douglas F. Levinson,

James B. Potash,

Joel Gelernter,

Shizhong Han

Publication year - 2017

Publication title -

jama psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.531

H-Index - 365

eISSN - 2168-6238

pISSN - 2168-622X

DOI - 10.1001/jamapsychiatry.2017.2269

Subject(s) - major depressive disorder , genome wide association study , alcohol dependence , medicine , alcohol use disorder , psychiatry , polygenic risk score , bipolar disorder , genetic association , psychology , clinical psychology , genetics , single nucleotide polymorphism , biology , alcohol , mood , genotype , gene , biochemistry

Major depressive disorder (MDD) and alcohol dependence (AD) are heritable disorders with significant public health burdens, and they are frequently comorbid. Common genetic factors that influence the co-occurrence of MDD and AD have been sought in family, twin, and adoption studies, and results to date have been promising but inconclusive.

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