Estimating the Heritability of Structural and Functional Brain Connectivity in Families Affected by Attention-Deficit/Hyperactivity Disorder | Zendy

Gustavo Sudre | Zendy; Saadia Choudhuri | Zendy; Eszter Székely | Zendy; Teighlor Bonner | Zendy; Elanda Goduni | Zendy; Wendy Sharp | Zendy; Philip Shaw | Zendy

Open Access

Estimating the Heritability of Structural and Functional Brain Connectivity in Families Affected by Attention-Deficit/Hyperactivity Disorder

Author(s) -

Gustavo Sudre,

Saadia Choudhuri,

Eszter Székely,

Teighlor Bonner,

Elanda Goduni,

Wendy Sharp,

Philip Shaw

Publication year - 2016

Publication title -

jama psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.531

H-Index - 365

eISSN - 2168-6238

pISSN - 2168-622X

DOI - 10.1001/jamapsychiatry.2016.3072

Subject(s) - heritability , corpus callosum , attention deficit hyperactivity disorder , diffusion mri , endophenotype , white matter , psychology , neuroimaging , functional magnetic resonance imaging , missing heritability problem , resting state fmri , neuroscience , magnetic resonance imaging , cognition , genetics , medicine , clinical psychology , biology , genetic variants , gene , radiology , genotype

Despite its high heritability, few risk genes have been identified for attention-deficit/hyperactivity disorder (ADHD). Brain-based phenotypes could aid gene discovery. There is a myriad of structural and functional connections that support cognition. Disruption of such connectivity is a key pathophysiologic mechanism for ADHD, and identifying heritable phenotypes within these connections could provide candidates for genomic studies.

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