Modeling Deficits From Early Auditory Information Processing to Psychosocial Functioning in Schizophrenia
Author(s) -
Michael L. Thomas,
Michael F. Green,
Gerhard Hellemann,
Catherine A. Sugar,
Melissa Tarasenko,
Monica E. Calkins,
Tiffany A. Greenwood,
Raquel E. Gur,
Ruben C. Gur,
Laura C. Lazzeroni,
Keith H. Nuechterlein,
Allen D. Radant,
Larry J. Seidman,
Alexandra L. Shiluk,
Larry J. Siever,
Jeremy M. Silverman,
Joyce Sprock,
William S. Stone,
Neal R. Swerdlow,
Debby W. Tsuang,
Ming T. Tsuang,
Bruce I. Turetsky,
David Braff,
Gregory A. Light
Publication year - 2016
Publication title -
jama psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.531
H-Index - 365
eISSN - 2168-6238
pISSN - 2168-622X
DOI - 10.1001/jamapsychiatry.2016.2980
Subject(s) - neurocognitive , psychology , cognition , schizoaffective disorder , schizophrenia (object oriented programming) , clinical psychology , psychosocial , endophenotype , mismatch negativity , wechsler adult intelligence scale , psychiatry , psychosis , electroencephalography
Neurophysiologic measures of early auditory information processing (EAP) are used as endophenotypes in genomic studies and biomarkers in clinical intervention studies. Research in schizophrenia has established correlations among measures of EAP, cognition, clinical symptoms, and functional outcome. Clarifying these associations by determining the pathways through which deficits in EAP affect functioning would suggest when and where to therapeutically intervene.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom