Positron Emission Tomographic Imaging of the Serotonergic System and Prediction of Risk and Lethality of Future Suicidal Behavior | Zendy

María A. Oquendo | Zendy; Hanga Galfalvy | Zendy; Gregory M. Sullivan | Zendy; Jeffrey M. Miller | Zendy; Matthew M. Milak | Zendy; M. Elizabeth Sublette | Zendy; Sebastian Cisneros-Trujillo | Zendy; Ainsley K. Burke | Zendy; Ramin V. Parsey | Zendy; J. John Mann | Zendy

Open Access

Positron Emission Tomographic Imaging of the Serotonergic System and Prediction of Risk and Lethality of Future Suicidal Behavior

Author(s) -

María A. Oquendo,

Hanga Galfalvy,

Gregory M. Sullivan,

Jeffrey M. Miller,

Matthew M. Milak,

M. Elizabeth Sublette,

Sebastian Cisneros-Trujillo,

Ainsley K. Burke,

Ramin V. Parsey,

J. John Mann

Publication year - 2016

Publication title -

jama psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.531

H-Index - 365

eISSN - 2168-6238

pISSN - 2168-622X

DOI - 10.1001/jamapsychiatry.2016.1478

Subject(s) - serotonin transporter , suicidal ideation , psychology , serotonergic , poison control , serotonin reuptake inhibitor , psychiatry , medicine , serotonin , suicide prevention , antidepressant , anxiety , emergency medicine , receptor

Biomarkers that predict suicidal behavior, especially highly lethal behavior, are urgently needed. In cross-sectional studies, individuals with depression who attempt suicide have lower midbrain serotonin transporter binding potential compared with those who do not attempt suicide, and higher serotonin1A binding potential in the raphe nuclei (RN) is associated with greater lethality of past suicide attempts and suicidal intent and ideation.

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