Dopamine-Related Disruption of Functional Topography of Striatal Connections in Unmedicated Patients With Schizophrenia | Zendy

Guillermo Horga | Zendy; Clifford Cassidy | Zendy; Xiaoyan Xu | Zendy; Holly Moore | Zendy; Mark Slifstein | Zendy; Jared X. Van Snellenberg | Zendy; Anissa AbiDargham | Zendy

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Dopamine-Related Disruption of Functional Topography of Striatal Connections in Unmedicated Patients With Schizophrenia

Author(s) -

Guillermo Horga,

Clifford Cassidy,

Xiaoyan Xu,

Holly Moore,

Mark Slifstein,

Jared X. Van Snellenberg,

Anissa AbiDargham

Publication year - 2016

Publication title -

jama psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.531

H-Index - 365

eISSN - 2168-6238

pISSN - 2168-622X

DOI - 10.1001/jamapsychiatry.2016.0178

Subject(s) - schizophrenia (object oriented programming) , psychology , psychosis , neuroscience , dopamine , dopaminergic , confounding , dopamine receptor d2 , striatum , functional magnetic resonance imaging , medicine , psychiatry

Despite the well-established role of striatal dopamine in psychosis, current views generally agree that cortical dysfunction is likely necessary for the emergence of psychotic symptoms. The topographic organization of striatal-cortical connections is central to gating and integration of higher-order information, so a disruption of such topography via dysregulated dopamine could lead to cortical dysfunction in schizophrenia. However, this hypothesis remains to be tested using multivariate methods ascertaining the global pattern of striatal connectivity and without the confounding effects of antidopaminergic medication.

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