Open AccessMediation of Developmental Risk Factors for Psychosis by White Matter Microstructure in Young Adults With Psychotic Experiences
Author(s) -
Mark Drakesmith,
Anirban Dutt,
Leon Fonville,
Stanley Zammit,
Abraham Reichenberg,
John Evans,
Glyn Lewis,
Derek K. Jones,
Anthony S. David
Publication year - 2016
Publication title -
jama psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.531
H-Index - 365
eISSN - 2168-6238
pISSN - 2168-622X
DOI - 10.1001/jamapsychiatry.2015.3375
Subject(s) - psychosis , psychology , young adult , white matter , mediation , developmental psychology , psychiatry , clinical psychology , medicine , magnetic resonance imaging , sociology , radiology , social science
White matter (WM) abnormalities have been identified in schizophrenia at the earliest stages of the disorder. Individuals in the general population with psychotic experiences (PEs) may show similar changes, suggesting dysfunction due to aberrant neurodevelopment. Studying such people is a powerful means of understanding the nature of neurodevelopmental problems without the confound of clinical management and allows other potential risk factors associated with the schizophrenia spectrum to be taken into account.
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