Early Childhood Depression and Alterations in the Trajectory of Gray Matter Maturation in Middle Childhood and Early Adolescence | Zendy

Joan L. Luby | Zendy; Andy C. Belden | Zendy; Joshua J. Jackson | Zendy; Christi. LessovSchlaggar | Zendy; Michael P. Harms | Zendy; Rebecca Tillman | Zendy; Kelly N. Botteron | Zendy; Diana J. Whalen | Zendy; Deanna M. Barch | Zendy

Open Access

Early Childhood Depression and Alterations in the Trajectory of Gray Matter Maturation in Middle Childhood and Early Adolescence

Author(s) -

Joan L. Luby,

Andy C. Belden,

Joshua J. Jackson,

Christi. LessovSchlaggar,

Michael P. Harms,

Rebecca Tillman,

Kelly N. Botteron,

Diana J. Whalen,

Deanna M. Barch

Publication year - 2015

Publication title -

jama psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.531

H-Index - 365

eISSN - 2168-6238

pISSN - 2168-622X

DOI - 10.1001/jamapsychiatry.2015.2356

Subject(s) - synaptic pruning , neuroimaging , psychology , childhood depression , early childhood , brain size , brain structure and function , magnetic resonance imaging , neuroscience , cognition , pediatrics , developmental psychology , audiology , medicine , radiology , microglia , inflammation

The trajectory of cortical gray matter development in childhood has been characterized by early neurogenesis and volume increase, peaking at puberty followed by selective elimination and myelination, resulting in volume loss and thinning. This inverted U-shaped trajectory, as well as cortical thickness, has been associated with cognitive and emotional function. Synaptic pruning-based volume decline has been related to experience-dependent plasticity in animals. To date, there have been no data to inform whether and how childhood depression might be associated with this trajectory.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research