Open AccessFunctional and Neuroanatomic Specificity of Episodic Memory Dysfunction in Schizophrenia
Author(s) -
J. Daniel Ragland,
Charan Ranganath,
Michael P. Harms,
Deanna M. Barch,
James M. Gold,
Evan Layher,
Tyler A. Lesh,
Angus W. MacDonald,
Tara A. Niendam,
Jennifer L. Phillips,
Steven M. Silverstein,
Andrew P. Yonelinas,
Cameron S. Carter
Publication year - 2015
Publication title -
jama psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.531
H-Index - 365
eISSN - 2168-6238
pISSN - 2168-622X
DOI - 10.1001/jamapsychiatry.2015.0276
Subject(s) - functional magnetic resonance imaging , psychology , schizophrenia (object oriented programming) , episodic memory , temporal lobe , cognitive psychology , dysfunctional family , prefrontal cortex , neuroscience , cognition , encoding (memory) , clinical psychology , psychiatry , epilepsy
Individuals with schizophrenia can encode item-specific information to support familiarity-based recognition but are disproportionately impaired encoding interitem relationships (relational encoding) and recollecting information. The Relational and Item-Specific Encoding (RiSE) paradigm has been used to disentangle these encoding and retrieval processes, which may depend on specific medial temporal lobe (MTL) and prefrontal cortex (PFC) subregions. Functional magnetic resonance (fMRI) imaging during RiSE task performance could help to specify dysfunctional neural circuits in schizophrenia that can be targeted for interventions to improve memory and functioning in the illness.
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