The Role of Parental Cognitive, Behavioral, and Motor Profiles in Clinical Variability in Individuals With Chromosome 16p11.2 Deletions | Zendy

Andrés Moreno-De-Luca | Zendy; David W. Evans | Zendy; K. B. Boomer | Zendy; Ellen Hanson | Zendy; Raphael Bernier | Zendy; Robin P. GoinKochel | Zendy; Scott M. Myers | Zendy; Thomas D. Challman | Zendy; Daniel MorenoDeLuca | Zendy; Mylissa M. Slane | Zendy; Abby Hare | Zendy; Wendy K. Chung | Zendy; John E. Spiro | Zendy; W. Andrew Faucett | Zendy; Alastair J. Martin | Zendy; David H. Ledbetter | Zendy

Open Access

The Role of Parental Cognitive, Behavioral, and Motor Profiles in Clinical Variability in Individuals With Chromosome 16p11.2 Deletions

Author(s) -

Andrés Moreno-De-Luca,

David W. Evans,

K. B. Boomer,

Ellen Hanson,

Raphael Bernier,

Robin P. GoinKochel,

Scott M. Myers,

Thomas D. Challman,

Daniel MorenoDeLuca,

Mylissa M. Slane,

Abby Hare,

Wendy K. Chung,

John E. Spiro,

W. Andrew Faucett,

Alastair J. Martin,

David H. Ledbetter

Publication year - 2014

Publication title -

jama psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.531

H-Index - 365

eISSN - 2168-6238

pISSN - 2168-622X

DOI - 10.1001/jamapsychiatry.2014.2147

Subject(s) - proband , penetrance , psychology , intraclass correlation , copy number variation , intelligence quotient , cognition , genetics , developmental psychology , biology , psychometrics , phenotype , psychiatry , mutation , genome , gene

Most disorders caused by copy number variants (CNVs) display significant clinical variability, often referred to as incomplete penetrance and variable expressivity. Genetic and environmental sources of this variability are not well understood.

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