Open AccessDeficits in Conditioned Fear Extinction in Obsessive-Compulsive Disorder and Neurobiological Changes in the Fear Circuit
Author(s) -
Mohammed R. Milad,
Sharon C. Furtak,
Jennifer L. Greenberg,
Aparna Keshaviah,
Jooyeon Jamie Im,
Martha J. Falkenstein,
Michael A. Jenike,
Scott L. Rauch,
Sabine Wilhelm
Publication year - 2013
Publication title -
jama psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.531
H-Index - 365
eISSN - 2168-6238
pISSN - 2168-622X
DOI - 10.1001/jamapsychiatry.2013.914
Subject(s) - ventromedial prefrontal cortex , psychology , extinction (optical mineralogy) , functional magnetic resonance imaging , posterior cingulate , anterior cingulate cortex , prefrontal cortex , fear conditioning , neuroscience , anxiety , anxiety disorder , audiology , amygdala , cognition , medicine , psychiatry , paleontology , biology
Obsessive-compulsive disorder (OCD) may be characterized by impaired self-regulation and behavioral inhibition. Elevated fear and anxiety are common characteristics of this disorder. The neurobiology of fear regulation and consolidation of safety memories have not been examined in this patient population.
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