Polygenic Risk and the Developmental Progression to Heavy, Persistent Smoking and Nicotine Dependence
Author(s) -
Daniel W. Belsky,
Terrie E. Moffitt,
Timothy B. Baker,
Andrea K. Biddle,
James P. Evans,
Hona Lee Harrington,
Renate Houts,
Madeline H. Meier,
Karen Sugden,
Benjamin Williams,
Richie Poulton,
Avshalom Caspi
Publication year - 2013
Publication title -
jama psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.531
H-Index - 365
eISSN - 2168-6238
pISSN - 2168-622X
DOI - 10.1001/jamapsychiatry.2013.736
Subject(s) - nicotine , smoking cessation , medicine , genome wide association study , nicotine replacement therapy , single nucleotide polymorphism , genetics , genotype , biology , pathology , gene
Genome-wide hypothesis-free discovery methods have identified loci that are associated with heavy smoking in adulthood. Research is needed to understand developmental processes that link newly discovered genetic risks with adult heavy smoking.
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